Abstract:

Abstract:Objective In order to provide a basis for the selection and application of the model of post-stroke depression in rats, the differences between the two most commonly used method for the preparation of the model of post-stroke depression in rats were compared by systematic evaluation. Method We searched Chinese and English databases including VIP, Wanfang, CNKI, Sinomed, PubMed, WOS, EMBASE on line, and collected all literatures about the post-stroke depression model in rats. Time limit was set since the establishment of the database to August 22nd, 2020. Literature screening and data extraction were conducted by two researchers independently. The quality of literatures was evaluated using the Systematic Review Centre for Laboratory animal Experimentation ( SYRCLE) animal experiment bias risk assessment tool, and reticulation meta-analysis was performed by Stata10. 0 software. Result A total of 998 rats were included in 51 studies. Among them, 809 rats received chronic unpredictable stress ( CUMS) in 42 studies after cerebral ischemia. While the chronic binding stress ( CRS) were carried out in of the rest of 9 studies including 199 rats. In terms of body weight, the availability of the two models was followed as CRS and CUMS, both of them showed significant weight loss since post-stress 14 d to 28 d ( P <0. 05) . However, for the sucrose preference rate, CUMS was superior to CRS, the former displayed significant decrease from post-stress 7 d ( P < 0. 05) , while the latter began at post-stress 14 d. Furthermore, CUMS model showed a significant difference from post-stress 7 d in the open field test ( P < 0. 05) , while CRS model appeared after 14 d of intervention ( P < 0. 05 ) . Conclusion The present study showed that rats received CUMS after cerebral ischemia was easier to produce depression-like behavior than the intervention of CRS.